The percent deviation was calculated. A quantity of 2 g of powder blend from each formula, previously shaken to break any agglomerates formed, was introduced in to 10 ml measuring cylinder.
Pregnancy and Fetal Injury Atenolol can cause fetal harm when administered to a pregnant woman. At three and six h after medication, the average reduction of IOP was 7. If the surfactant is hydrophilic, thenoil will be emulsified in droplets throughout a continuous water phase.
This observation led to the conclusion that the micro emulsion eye drops have a real advantage compared to regular eye drops which must be administered four times a day due to the short duration of the Formulation evalution of atenolol hcl action.
Patients in the atenolol group were to receive atenolol injection 5 to 10 mg given over 5 minutes plus Atenolol Tablets 50 mg every 12 hours orally on the first study day the first oral dose administered about 15 minutes after the IV dose followed by either Atenolol Tablets mg once daily or Atenolol Tablets 50 mg twice daily on days 2 to 7.
These considerations may guide selection of therapy. Pre formulation studies were performed on the drug, which included melting point determination, solubility and compatibility studies.
In the present study, it has been observed that there is no chemical interaction between Atenolol and the polymers used. In vitro release profile of floating bioadhesive tablets of atenolol.
Kinetic studies To analyze the release mechanism, several release models were tested such as: Compatibility studies were performed using IR spectrophotometer. Atenolol Tablets, for oral administration, are available as 25 mg, 50 mg and mg tablets.
Where Q t is the amount of drug released at time t, Ko is the apparent dissolution rate constant or zero order release constant and Qo is the initial concentration of the drug in the solution resulting from a burst effect; in Formulation evalution of atenolol hcl case the drug release runs as a constant rate.
Hydrophilic drugs penetrate primarily through the paracellular pathway which involves passive or altered diffusion through intercellular spaces, for most topically applied drugs, passive diffusion along their concentration gradient, either transcellularly or paracellularly, is the main permeation mechanism across the cornea .
The microstructure is constantly changing, making these very dynamic systems with reversible droplet coalescence . The last two complications may occur with or without preceding exacerbation of the angina pectoris.
Surfactants are surface-active molecules. Elevated systolic or diastolic pressure causes increased cardiovascular risk, and the absolute risk increase per mmHg is greater at higher blood pressures, so that even modest reductions of severe hypertension can provide substantial benefit.
This is a dynamic process. There is diffusion of molecules within the microstructures and there are fluctuations in the curvature of the surfactant film.
To study weight variation twenty tablets of the formulation were weighed using a Essae electronic balance and the test was performed according to the official method. The two sides of the balance were made equal before the study, by keeping 5 g weight on the right hand pan.
Initial and subsequent atenolol dosages can be adjusted downward depending on clinical observations including pulse and blood pressure.
The return to the initial values was noticed within 12 h [28,29]. It was determined by measuring the volume occupied by the blend and true volume of the blend.
Melting point of Atenolol was determined by capillary method. Behind the relative straightforward composition nature of ophthalmic solutions and ointments, however, like many physicochemical parameters which affect drug stability, safety and efficacy as they do most other products.
According to Naveh et al. Formulation and evaluation of Mouth Dissolving Tablets of Oxacarbazepine. The Hausner ration was found between1. This kinetic profile results in relatively consistent plasma drug levels with about a fourfold interpatient variation. Atenolol is a beta-adrenergic blocking agent that blocks the effects of adrenergic drugs.Formulation and evaluation of gastro retentive floating drug delivery system of Atenolol Composition of different formulations Formulation No.
Atenolol (mg) HPMC K15M (mg) HPMC KM (mg) NaHCO 3 (mg) Mag. Stearate (mg) Talc adjusted to ml with N HCl. Further 1ml of the above. Atenolol Tablets official prescribing information for healthcare professionals.
renal, or cardiac function, and of concomitant disease or other drug therapy. Evaluation of patients with hypertension or myocardial infarction should always include assessment of renal function. is an easy-to-swallow, thickened, oral suspension formulation.
Formulation and Evaluation of Sustained Release Mucoadhesive Atenolol Tablets for Gastric Retention Sunena Jha1*, Keywords: Mucoadhesion, Gastroretentive drug delivery,Atenolol HCl, Carbopol P, Sodium Carboxymethyl Cellulose (CMC).
Formulation Development and In-Vitro Evaluation of Gastroretentive Floating tablets of Atenolol polonyauniversitem.comarathi, polonyauniversitem.com*, polonyauniversitem.comuthu Kumar, polonyauniversitem.comlan.
In this study, mouth-disintegrating tablets of atenolol and atorvastatin combination were formulated using superdisintegrants to impart fast disintegration.
Fifteen formulations were prepared based on different concentrations of two superdisintegrants, croscarmellose sodium and Kyron-T FORMULATION AND EVALUATION OF FLOATING MATRIX TABLET OF ATENOLOL FOR formulation of atenolol should contain a total dose of mg (≈50mg) and should release 25 mg in 1 h like conventional tablets, and mg per hour up to 12 h thereafter.
HCl (pH ) maintained at 37±°C.Download